替莫唑胺
坏死性下垂
活性氧
医学
胶质母细胞瘤
胶质瘤
癌症研究
药品
药理学
达卡巴嗪
生物
细胞凋亡
黑色素瘤
程序性细胞死亡
细胞生物学
生物化学
作者
Fanchen Wang,Lixia Xu,Binli Wen,Sirong Song,Yan Zhou,Haiyang Wu,Qiaoli Wu,Yinsong Wang,Xiaoguang Tong,Hua Yan
出处
期刊:Cancer Letters
[Elsevier]
日期:2023-02-01
卷期号:554: 216033-216033
被引量:8
标识
DOI:10.1016/j.canlet.2022.216033
摘要
Temozolomide (TMZ) has been determined to be the chemotherapeutic drug with efficacy for glioblastoma (GBM). Thus, potentiating the therapeutic effect of TMZ can undoubtedly yield twice the result with half the effort. In this study, we found for the first time that TMZ can produce reactive oxygen species (ROS) under the influence of ultrasound (US). This property allows TMZ-US therapy to have better efficacy in the treatment of GBM. Given that the increasing use of US in central nervous system (CNS) diseases and the importance of TMZ for GBM therapy, our results will facilitate the development of TMZ-associated glioblastoma therapies. Moreover, we found that chemotherapeutic drugs might have the ability to generate ROS under the excitation of US. On a larger scale, our findings may be applicable to a wide range of known drugs.
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