The widespread implementation of intrathecal infusion systems (IIS) in managing chronic pain underscores the pivotal role of family caregivers in ensuring effective treatment outcomes and enhancing patients' quality of life. We conducted a comprehensive literature search across databases including PubMed, Medline, and Web of Science. Research indicates that family caregivers primarily face barriers such as insufficient professional knowledge, technical difficulties, psychological and emotional strain, and a lack of adequate financial and social support. These challenges can compromise the efficacy of pain management and increase caregivers' burdens. In response, recent studies have concentrated on offering targeted educational programs and training, fostering support networks, and encouraging technological innovations and policy reforms. Such initiatives aim to bolster caregivers' capabilities and alleviate their psychological and financial stress, thereby enhancing the overall effectiveness of pain management strategies. The significance of the review is that it highlights the central role of family carers in chronic pain management and points to the importance of enhancing their caring capacity. Future research directions should include the development of more systematic caregiver support programs, an in-depth exploration of the effectiveness of multidisciplinary collaborative models, and an assessment of the promise of emerging technologies for use in the family caregiving environment.