CD206 + IL-4Rα + Macrophages Are Drivers of Adverse Cardiac Remodeling in Ischemic Cardiomyopathy

Cardiac CD206⁺IL-4Rα⁺ macrophages proliferate and expand in HF and are key mediators of pathological remodeling and fibrosis, in part through the secretion of FIZZ1. Inhibition of CD206⁺ macrophage IL-4Rα signaling alleviates LV remodeling in ischemic cardiomyopathy.