大肠杆菌
硼酸
抗菌剂
化学
抗菌活性
细菌细胞结构
碳纤维
纳米材料
共价键
微生物学
细菌
核化学
组合化学
纳米技术
材料科学
有机化学
复合数
生物化学
生物
基因
遗传学
复合材料
作者
Lingling Zhao,Yue Ma,Zhaomeng Sun,Xiaoqing Zhang,Mei Liu
出处
期刊:Langmuir
[American Chemical Society]
日期:2023-12-06
卷期号:39 (50): 18302-18310
标识
DOI:10.1021/acs.langmuir.3c02314
摘要
Bacterial infections and antibiotic abuse are a global threat to human health. In recent years, there has been a boom in research on antimicrobial agents with low toxicity and efficient nanomaterials. Boric acid-functionalized carbon dots (B-CDs) with negative surface charge were synthesized by the hydrothermal method. Covalent bonds were formed between the boric acid groups and the cis-diol groups of the polysaccharide in the bacterial cell wall, and numerous B-CDs were trapped on the bacterial surface. In the experiments of antibacterial activity, B-CDs presented strong bactericidal activity against Escherichia coli (E. coli) with a minimum bactericidal concentration of 12.5 μg/mL. The antibacterial mechanism suggested that B-CDs entered the cell interior by diffusion and posed significant damage to the double helix structure of E. coli DNA. Furthermore, B-CDs exhibited low toxicity. The results demonstrated that the novel antimicrobial B-CDs not only fought against E. coli infection and antibiotic misuse but also provided new ideas for safe and effective antimicrobial agents of carbon nanomaterials.
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