免疫原
免疫系统
佐剂
抗原
淋巴
免疫学
接种疫苗
淋巴系统
生物
免疫
滤泡树突状细胞
获得性免疫系统
体液免疫
免疫
抗体
医学
抗原提呈细胞
T细胞
病理
单克隆抗体
作者
Aereas Aung,Darrell J. Irvine
标识
DOI:10.4049/jimmunol.2300500
摘要
Abstract Primary immune responses following vaccination are initiated in draining lymph nodes, where naive T and B cells encounter Ag and undergo coordinated steps of activation. For humoral immunity, the amount of Ag present over time, its localization to follicles and follicular dendritic cells, and the Ag’s structural state all play important roles in determining the subsequent immune response. Recent studies have shown that multiple elements of vaccine design can impact Ag availability in lymphoid tissues, including the choice of adjuvant, physical form of the immunogen, and dosing kinetics. These vaccine design elements affect the transport of Ag to lymph nodes, Ag’s localization in the tissue, the duration of Ag availability, and the structural integrity of the Ag. In this review, we discuss these findings and their implications for engineering more effective vaccines, particularly for difficult to neutralize pathogens.
科研通智能强力驱动
Strongly Powered by AbleSci AI