Rutin-decorated molybdenum disulfide / hyaluronic acid methylprenyl hydrogel photothermal antibacterial therapy promotes skin wound repair

This study aimed to develop a multifunctional hydrogel for skin wound healing by encapsulating rutin-modified molybdenum disulfide (MoS₂) within methacrylated hyaluronic acid (HAMA). Rutin, a natural flavonoid, was employed to stabilize MoS₂ dispersion and enable sustained release, thereby promoting fibroblast proliferation. Scanning electron microscopy revealed improved dispersion of rutin-modified MoS₂ within the HAMA hydrogel matrix. Under near-infrared (NIR) irradiation, MoS₂ demonstrated robust photothermal effects, significantly reducing bacterial viability of both Escherichia coli and Staphylococcus aureus. The sustained release of rutin synergistically enhanced photothermal antibacterial efficacy while concurrently accelerating fibroblast proliferation, collectively contributing to superior cutaneous wound repair. This dual-modal functionality addresses the critical trade-off between rapid bacterial eradication and long-term tissue repair, providing a translatable therapeutic strategy for wound regeneration scenarios. .