癌变
重编程
翻译（生物学）
生物
癌症研究
髓系白血病
白血病
癌症
遗传学
基因
信使核糖核酸
作者
Chao Shen,Yuan Che,Keren Zhou,Kitty Wang,Wei Li,D. S. Xue,Tong Wu,Lu Yang,Meiling Chen,Yue Sheng,Chengwan Zhang,Sean Robinson,Huiying Chen,Lillian Sau,Zhenhua Chen,Mark Wunderlich,Li Han,Tingting Tang,Ying Qing,Dong Wu
出处
期刊：Cancer Discovery
[American Association for Cancer Research]
日期：2025-08-01
卷期号：15 (11): 2298-2325
被引量：5
标识
DOI：10.1158/2159-8290.cd-24-1043
摘要
This study uncovers that ALKBH1-driven tRNA-decoding reprogramming and codon-biased translation, termed "epitranslatomic Midas touch," is crucial for leukemogenesis, leukemia stem cell/leukemia-initiating cell self-renewal, mitochondria structure/function, and resistance to venetoclax. Targeting ALKBH1, especially in combination with venetoclax, offers a promising therapeutic strategy to combat drug resistance in AML and potentially other ALKBH1-overexpressing cancers.
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(2025-6-4)
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