Targeting ADAMTS-7: A Vaccination Against Atherosclerosis—and Its Complications?

HomeCirculationVol. 147, No. 9Targeting ADAMTS-7: A Vaccination Against Atherosclerosis—and Its Complications? No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextTargeting ADAMTS-7: A Vaccination Against Atherosclerosis—and Its Complications? Thorsten Kessler, MD and Heribert Schunkert, MD Thorsten KesslerThorsten Kessler https://orcid.org/0000-0003-3326-1621 German Heart Centre Munich, Department of Cardiology, Technical University of Munich, Germany. German Centre for Cardiovascular Research (DZHK eV), partner site Munich Heart Alliance, Germany. Search for more papers by this author and Heribert SchunkertHeribert Schunkert Correspondence to: Heribert Schunkert, MD, German Heart Centre Munich, Department of Cardiology, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany. Email E-mail Address: [email protected] https://orcid.org/0000-0001-6428-3001 German Heart Centre Munich, Department of Cardiology, Technical University of Munich, Germany. German Centre for Cardiovascular Research (DZHK eV), partner site Munich Heart Alliance, Germany. Search for more papers by this author Originally published27 Feb 2023https://doi.org/10.1161/CIRCULATIONAHA.122.063495Circulation. 2023;147:743–745This article is a commentary on the followingPeptide Vaccine Against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima HyperplasiaFootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Sources of Funding and Disclosures, see page 745.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Heribert Schunkert, MD, German Heart Centre Munich, Department of Cardiology, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany. Email [email protected]mhn.deReferences1. Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M, Hindy G, Zhou W, et al. Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.Nat Genet. 2022; 54:1803–1815. doi: 10.1038/s41588-022-01233-6CrossrefMedlineGoogle Scholar2. Chyu K-Y, Shah PK. In pursuit of an atherosclerosis vaccine.Circ Res. 2018; 123:1121–1123. doi: 10.1161/circresaha.118.313842LinkGoogle Scholar3. Nilsson J, Hansson GK. Vaccination strategies and immune modulation of atherosclerosis.Circ Res. 2020; 126:1281–1296. doi: 10.1161/CIRCRESAHA.120.315942LinkGoogle Scholar4. Ma Z, Mao C, Chen X, Yang S, Qiu Z, Yu B, Jia Y, Wu C, Wang Y, Wang Y, et al. Peptide vaccine against ADAMTS-7 ameliorates atherosclerosis and postinjury neointima hyperplasia.Circulation. 2023; 147:728–742. doi: 10.1161/CIRCULATIONAHA.122.061516LinkGoogle Scholar5. Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, Burnett MS, Devaney JM, Knouff CW, Thompson JR, et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.Lancet. 2011; 377:383–392. doi: 10.1016/s0140-6736(10)61996-4CrossrefMedlineGoogle Scholar6. Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AFR, Barbalic M, Gieger C, et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.Nat Genet. 2011; 43:333–338. doi: 10.1038/ng.784CrossrefMedlineGoogle Scholar7. Wang L, Zheng J, Bai X, Liu B, Liu C-J, Xu Q, Zhu Y, Wang N, Kong W, Wang X. ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries.Circ Res. 2009; 104:688–698. doi: 10.1161/CIRCRESAHA.108.188425LinkGoogle Scholar8. Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, et al. ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1.Circulation. 2015; 131:1191–1201. doi: 10.1161/CIRCULATIONAHA.114.014072LinkGoogle Scholar9. Bauer RC, Tohyama J, Cui J, Cheng L, Yang J, Zhang X, Ou K, Paschos GK, Zheng XL, Parmacek MS, et al. Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice.Circulation. 2015; 131:1202–1213. doi: 10.1161/CIRCULATIONAHA.114.012669LinkGoogle Scholar10. Mizoguchi T, MacDonald BT, Bhandary B, Popp NR, Laprise D, Arduini A, Lai D, Zhu QM, Xing Y, Kaushik VK, et al. Coronary disease association with ADAMTS7 is due to protease activity.Circ Res. 2021; 129:458–470. doi: 10.1161/CIRCRESAHA.121.319163LinkGoogle Scholar11. Cassese S, Byrne RA, Schulz S, Hoppman P, Kreutzer J, Feuchtenberger A, Ibrahim T, Ott I, Fusaro M, Schunkert H, et al. Prognostic role of restenosis in 10 004 patients undergoing routine control angiography after coronary stenting.Eur Heart J. 2014; 36:94–99. doi: 10.1093/eurheartj/ehu383CrossrefMedlineGoogle Scholar12. Winkler MJ, Müller P, Sharifi AM, Wobst J, Winter H, Mokry M, Ma L, van der Laan SW, Pang S, Miritsch B, et al. Functional investigation of the coronary artery disease gene SVEP1.Basic Res Cardiol. 2020; 115:67. doi: 10.1007/s00395-020-00828-6CrossrefMedlineGoogle Scholar13. Stitziel NO, Stirrups KE, Masca NGD, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL, et al; Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators. Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease.N Engl J Med. 2016; 374:1134–1144. doi: 10.1056/NEJMoa1507652CrossrefMedlineGoogle Scholar14. Spinale FG, Frangogiannis NG, Hinz B, Holmes JW, Kassiri Z, Lindsey ML. Crossing into the next frontier of cardiac extracellular matrix research.Circ Res. 2016; 119:1040–1045. doi: 10.1161/CIRCRESAHA.116.309916LinkGoogle Scholar15. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease.N Engl J Med. 2017; 377:1119–1131. doi: 10.1056/nejmoa1707914CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesPeptide Vaccine Against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima HyperplasiaZihan Ma, et al. Circulation. 2023;147:728-742 February 28, 2023Vol 147, Issue 9 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.122.063495PMID: 36848412 Originally publishedFebruary 27, 2023 Keywordscoronary artery diseasevaccinationEditorialsatherosclerosisPDF download Advertisement SubjectsMechanismsTranslational StudiesVascular Biology