高铁F1
癌变
昼夜节律
克拉斯
肺癌
生物
癌症研究
癌症
生物信息学
热休克蛋白
内科学
内分泌学
遗传学
医学
基因
结直肠癌
热休克蛋白70
作者
Marie Pariollaud,Lara H. Ibrahim,Emanuel Irizarry,Rebecca M. Mello,Alanna B. Chan,Brian J. Altman,Reuben J. Shaw,Michael J. Bollong,R. Luke Wiseman,Katja A. Lamia
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2022-09-30
卷期号:8 (39)
标识
DOI:10.1126/sciadv.abo1123
摘要
Disrupted circadian rhythmicity is a prominent feature of modern society and has been designated as a probable carcinogen by the World Health Organization. However, the biological mechanisms that connect circadian disruption and cancer risk remain largely undefined. We demonstrate that exposure to chronic circadian disruption [chronic jetlag (CJL)] increases tumor burden in a mouse model of KRAS-driven lung cancer. Molecular characterization of tumors and tumor-bearing lung tissues revealed that CJL enhances the expression of heat shock factor 1 (HSF1) target genes. Consistently, exposure to CJL disrupted the highly rhythmic nuclear trafficking of HSF1 in the lung, resulting in an enhanced accumulation of HSF1 in the nucleus. HSF1 has been shown to promote tumorigenesis in other systems, and we find that pharmacological or genetic inhibition of HSF1 reduces the growth of KRAS-mutant human lung cancer cells. These findings implicate HSF1 as a molecular link between circadian disruption and enhanced tumorigenesis.
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