介孔二氧化硅
纳米颗粒
荧光
纳米技术
混合材料
材料科学
胶束
共聚物
生物分子
生物传感器
水溶液
化学
介孔材料
聚合物
有机化学
物理
复合材料
催化作用
量子力学
作者
Shaobo Yang,Yongsheng Li
摘要
Abstract Benefitting from the subtle combination of robust inorganic silica with organic dyes, fluorescent hybrid silica nanoparticles are getting more and more attention by virtue of their excellent aqueous solubility, superior photo‐ and chemical stability, negligible cytotoxicity, and multifunctional capability. On overcoming the disadvantages of traditional organic dyes, fluorescent hybrid silica nanoparticles have exhibited promising biomedical application potentials both in vitro and in vivo, such as bioimaging, anti‐tumor theranostics and biosensing, etc. In this review, various fluorescent hybrid materials based on colloidal silica nanoparticles, mesoporous silica nanoparticles and silica‐block copolymer hybrid micelles are discussed from the design, synthesis to their biomedical applications. Especially, the fluorescent hybrid silica/organosilica cross‐linking block copolymer micelles are introduced in detail. Finally, the prospects and challenges of these fluorescent hybrid silica nanoparticles in terms of their design, synthesis, and biomedical application are presented. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
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