化学
环氧乙烷
电化学
组合化学
催化作用
天然产物
立体化学
有机化学
电极
物理化学
作者
Lukas Anton Wein,Klaus Wurst,Péter Angyal,Lara Weisheit,Thomas Magauer
摘要
We present a bioinspired late-stage C–H oxidation of the ent-trachylobane natural product mitrephorone B to mitrephorone A. The realization of this unprecedented transformation was accomplished by either an iron-catalyzed or electrochemical oxidation and enabled access to the densely substituted oxetane in one step. Formation of mitrephorone C, which is lacking the central oxetane unit but features a keto-function at C2, was not formed under these conditions.
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