Research progress of pseudomonas aeruginosa quorum sensing inhibitors

Pseudomonas aeruginosa is an opportunistic pathogen with severe antibiotic resistance problems, challenging the use of traditional antibiotics. Quorum sensing is a phenomenon of cell density dependent control of gene expression which controls the expression of virulence factors and biofilm formation in pseudomonas aeruginosa. Inhibition of quorum sensing can reduce the virulence of pseudomonas aeruginosa but shows no selection pressure thus making it a potential anti-infection strategy which is less likely to cause resistance. This review presents the research progress of pseudomonas aeruginosa quorum sensing inhibitors in recent years. Key words: Pseudomonas aeruginosa; Quorum sensing; Inhibitor