Evaluation of myocardial injury markers in the diagnosis of pediatric myocardial injury diseases

Pediatric cardiac injury is common in primary heart disease and secondary systemic diseases. The pathophysiological processes include ischemic injury or direct injury, as well as focal or diffuse myocardial inflammatory lesions. Myocardial injury markers, including myoglobin, creatine kinase isoenzyme muscle B and troponin, are first used for the diagnosis of acute coronary syndrome(ACS) in adult, and have greatly improved the efficiency of diagnosis with their sensitivity and specificity. However, due to the very different pathogenesis of myocardial injury in pediatric and adult ACS, as well as the particularity that children are in continuous growth and development, it is necessary to evaluate the value of the myocardial injury markers and their biological reference intervals in pediatrics. (Chin J Lab Med, 2015, 38: 370-372) Key words: Cardiomyopathies; Biological markers; Reference values; Child