免疫学
免疫
免疫记忆
获得性免疫系统
2019年冠状病毒病(COVID-19)
疾病
冠状病毒
CD8型
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
病毒学
免疫系统
病毒
生物
医学
传染病(医学专业)
内科学
作者
Jennifer M. Dan,José Mateus,Yu Kato,Kathryn M. Hastie,Esther Dawen Yu,Caterina E. Faliti,Alba Grifoni,Sydney I. Ramirez,Sonya Haupt,April Frazier,Catherine Nakao,Vamseedhar Rayaprolu,Stephen A. Rawlings,Bjoern Peters,Florian Krammer,Viviana Simon,Erica Ollmann Saphire,Davey M Smith,Daniela Weiskopf,Alessandro Sette,Shane Crotty
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-02-05
卷期号:371 (6529)
被引量:2255
标识
DOI:10.1126/science.abf4063
摘要
Variable memory Immune memory against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) helps to determine protection against reinfection, disease risk, and vaccine efficacy. Using 188 human cases across the range of severity of COVID-19, Dan et al. analyzed cross-sectional data describing the dynamics of SARS-CoV-2 memory B cells, CD8 + T cells, and CD4 + T cells for more than 6 months after infection. The authors found a high degree of heterogeneity in the magnitude of adaptive immune responses that persisted into the immune memory phase to the virus. However, immune memory in three immunological compartments remained measurable in greater than 90% of subjects for more than 5 months after infection. Despite the heterogeneity of immune responses, these results show that durable immunity against secondary COVID-19 disease is a possibility for most individuals. Science , this issue p. eabf4063
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