邻苯二甲酸盐
氧化应激
丙二醛
肾
内分泌学
内科学
化学
谷胱甘肽
毒性
医学
生物化学
有机化学
酶
作者
Yue Gu,Mengchun Gao,Wenwen Zhang,Yan Liang,Fengmin Shao,Jing Zhou
出处
期刊:Chemosphere
[Elsevier]
日期:2021-05-01
卷期号:271: 129740-129740
被引量:35
标识
DOI:10.1016/j.chemosphere.2021.129740
摘要
Di(2-ethylhexyl) phthalate (DEHP) has been well acknowledged for its endocrine disruption and associated metabolic diseases, leading to the search for safer industrial alternatives including di-isononyl phthalate (DINP). However, safety data for the latter chemical has been relatively scarce particularly regarding potential damage to the kidney at low doses. Five-week-old ICR male mice were exposed to vehicle, DEHP or DINP (0.05 and 4.8 mg/kg bw) daily via gavage for 5 weeks. We observed increased levels of reactive oxygen species and malondialdehyde, decreased levels of reduced glutathione, in the kidney at higher dose for both chemicals suggestive of oxidative damage. Elevated levels of inflammatory cytokines tumor necrosis factor-α and interleukin-6 of the kidney further suggested inflammatory status as a result of phthalate exposure in both high dose groups. Targeted lipidomics demonstrated greatest changes in the kidney induced by high dose of DEHP, although DINP also induced significant changes in phospholipids diacylglycerides that are associated with lipid accumulation in glomerular podocytes and inflammatory responses. Our data suggest that oxidative stress may be involved in both DEHP- and DINP-induced renal lipidomic disruption and continue to question the suitability of DINP as proper DEHP substitute.
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