肌酐
内科学
肾功能
医学
糖尿病肾病
内分泌学
蛋白尿
糖尿病
白蛋白
泌尿系统
泌尿科
作者
Safaa I. Tayel,Amany A. Saleh,Sally M El-Hefnawy,Khaled Mohamed Amin Elzorkany,Ghada E Elgarawany,Rasha I. Noreldin
出处
期刊:Current Molecular Medicine
[Bentham Science]
日期:2020-04-28
卷期号:20 (5): 361-371
被引量:8
标识
DOI:10.2174/1566524019666191019103918
摘要
Background and Aim: Diabetic nephropathy (DN) is a major determinant of end-stage renal disease (ESRD). Altered microRNA levels lead to serious chronic diseases, such as diabetes. We aimed to measure the expression levels of two microRNAs, microRNA126 and 192 in DN and investigate their connection with albuminuria levels. Methods: This study included 229 subjects (134 DN patients and 95 controls). Serum lipid profiles, glucose levels, glycated haemoglobin (HbA1c) levels, and renal functions were assayed. The microRNA126 and microRNA192 expression levels were determined by real-time PCR. Results: Patients with DN had higher weights, BMI values, glucose levels (p<0.001), HbA1c levels (p<0.001), urinary albumin-creatinine ratio (ACR) values (p<0.001), urea levels (P=0.002), and creatinine levels (P=0.004) and lower expression levels of both microRNA192 (p<0.001) and microRNA126 (p<0.001) than controls. MicroRNA126 expression was positively correlated with age, estimated glomerular filtration rate (eGFR) and microRNA192 expression but negatively correlated with blood sugar, HbA1c, urea, creatinine and ACR. MicroRNA192 had higher sensitivity (91%), specificity (94%), and area under the curve (AUC) (0.967) values than microRNA126 (sensitivity, 90%; specificity, 68%; AUC, 0.897) and thus can precisely diagnose DN. Conclusion: Both MicroRNA126 and microRNA192 expression were obviously associated with DN and might determine the progression of the disease owing to prominent relation with macroalbuminuria.
科研通智能强力驱动
Strongly Powered by AbleSci AI