碱基
纳米孔
石墨烯
DNA
电导
纳米孔测序
纳米技术
DNA测序
自相关
A-DNA
序列(生物学)
材料科学
生物系统
化学
物理
生物
统计
生物化学
数学
凝聚态物理
作者
Seung Kyu Min,Woo Youn Kim,Yeonchoo Cho,Kwang S. Kim
标识
DOI:10.1038/nnano.2010.283
摘要
Devices in which a single strand of DNA is threaded through a nanopore could be used to efficiently sequence DNA. However, various issues will have to be resolved to make this approach practical, including controlling the DNA translocation rate, suppressing stochastic nucleobase motions, and resolving the signal overlap between different nucleobases. Here, we demonstrate theoretically the feasibility of DNA sequencing using a fluidic nanochannel functionalized with a graphene nanoribbon. This approach involves deciphering the changes that occur in the conductance of the nanoribbon as a result of its interactions with the nucleobases via π-π stacking. We show that as a DNA strand passes through the nanochannel, the distinct conductance characteristics of the nanoribbon (calculated using a method based on density functional theory coupled to non-equilibrium Green function theory) allow the different nucleobases to be distinguished using a data-mining technique and a two-dimensional transient autocorrelation analysis. This fast and reliable DNA sequencing device should be experimentally feasible in the near future.
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