肌醇
第二信使系统
调节器
磷脂酰肌醇
聚磷酸盐
细胞生物学
磷酸肌醇
信号转导
磷脂酰肌醇4,5-二磷酸
生物化学
转录调控
生物
化学
转录因子
受体
磷酸盐
基因
作者
Eunha Kim,Jiyoon Beon,Seulgi Lee,Jina Park,Se-Yun Kim
出处
期刊:Advances in biological regulation
日期:2016-05-01
卷期号:61: 25-32
被引量:31
标识
DOI:10.1016/j.jbior.2015.11.005
摘要
Inositol-derived metabolites (e.g., phosphoinositides and inositol polyphosphates) are key second messengers that are essential for controlling a wide range of cellular events. Inositol polyphosphate multikinase (IPMK) exhibits complex catalytic activities that eventually yield water-soluble inositol polyphosphates (e.g., IP4 and IP5) and lipid-bound phosphatidylinositol 3,4,5-trisphosphate. A series of recent studies have suggested that IPMK may be a multifunctional regulator in the nucleus of mammalian cells. In this review, we highlight the novel modes of action of IPMK in transcriptional and epigenetic regulation, and discuss its roles in physiology and disease.
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