Fenton‐RAFT Polymerization: An “On‐Demand” Chain‐Growth Method

Abstract Fine control over the architecture and/or microstructure of synthetic polymers is fast becoming a reality owing to the development of efficient and versatile polymerization techniques and conjugation reactions. However, the transition of these syntheses to automated, programmable, and high‐throughput operating systems is a challenging step needed to translate the vast potential of precision polymers into machine‐programmable polymers for biological and functional applications. Chain‐growth polymerizations are particularly appealing for their ability to form structurally and chemically well‐defined macromolecules through living/controlled polymerization techniques. Even using the latest polymerization technologies, the macromolecular engineering of complex functional materials often requires multi‐step syntheses and purification of intermediates, and results in sub‐optimal yields. To develop a proof‐of‐concept of a framework polymerization technique that is readily amenable to automation requires several key characteristics. In this study, a new approach is described that is believed to meet these requirements, thus opening avenues toward automated polymer synthesis.