The essential oil from the leaves of grapefruit mint (Mentha suaveolens ×piperita) grown in China was isolated by hydrodistillation (HD). The oil obtained with 1.08% yields was analyzed by GC and GC-MS. Twenty-eight components have been identified in the HD essential oil of grapefruit mint. Linalool (41.50%) and linalyl anthranilate (33.75%) are the two main components of the essential oil of leaves, followed by α-terpineol (6.29%), geranyl acetate (3.67%), nerol acetate (2.09%), and trans-geraniol (2.07%).