Noninvasive Detection of Cardiac Amyloid With 11C-Pittsburgh Compound B PET/CT and 99mTc-PYP Scintigraphy

Abstract We report the imaging findings of 2 cases of cardiac amyloidosis, one light chain (AL) type and another transthyretin (ATTR) type. The images showed 11 C-Pittsburgh compound B ( 11 C-PIB) uptake in the heart with AL amyloidosis, whereas the ATTR amyloidosis showed 11 C-PIB–negative and 99m Tc-PYP–positive uptake in the heart. It demonstrated that using 99m Tc-PYP scintigraphy and 11 C-PIB PET/CT might be able to differentiate these 2 major types of cardiac amyloidosis noninvasively.