医学
单变量分析
内科学
逻辑回归
CYP2C9
VKORC1型
基因型
多态性(计算机科学)
病历
胺碘酮
华法林
等位基因
基因多态性
胃肠病学
等位基因频率
单核苷酸多态性
优势比
作者
Xiaotong Xia,Jinglan Fu,Tingting Wu,Wenjun Chen,Shaojun Jiang,Meina Lv,Jinhua Zhang
标识
DOI:10.1007/s00228-021-03204-y
摘要
The purpose of this study was to analyse the effects of demographic factors, clinical factors, and genetic polymorphisms of related gene loci on warfarin bleeding-related complications in the Han population.Retrospective medical record review. The study cases were patients treated at the Fujian Medical University Union Hospital from March 2016 to February 2020, and all received regular warfarin anticoagulation treatment for at least 3 months, and were provided the initial standard dose and stable dose of warfarin.Data were collected from 451 qualifying patients (47% male, 53% female). The average age of patients was 53.8 ± 12.2 years, and the average body surface area was 1.6 ± 0.18 m2. There were nine major bleeding events and 141 minor bleeding events. In the univariate logistic analysis, the p-value of the four factors body weight, body surface area (BSA), amiodarone, and rs429358 was < 0.10. However, the final p-values for amiodarone and rs429358 were < 0.05 in the multifactorial logistic analysis.The ApoE (rs429358) gene polymorphism influences bleeding complications in Chinese Han patients treated with warfarin. The sample size of this study was relatively small; hence an international study with a larger sample size is needed in the future.
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