心力衰竭
社会经济地位
DNA甲基化
甲基化
内科学
种族差异
医学
心脏病学
作者
Mark E Pepin,Chae-Myeong Ha,Luke A Potter,Sayan Bakshi,Joseph Barchue,Ayman Haj Asaad,Steven M. Pogwizd,Salpy V. Pamboukian,Bertha Hidalgo,Selwyn M. Vickers,Adam R. Wende
出处
期刊:American Journal of Physiology-heart and Circulatory Physiology
[American Physiological Society]
日期:2021-03-26
被引量:6
标识
DOI:10.1152/ajpheart.00036.2021
摘要
A bimodal signature of cardiac DNA methylation in heart failure corresponds with racial differences in all-cause mortality following mechanical circulatory support. Racial differences in promoter methylation disproportionately affect metabolic signaling pathways. Socioeconomic factors are associated with racial differences in the cardiac methylome among men with end-stage heart failure.
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