视神经脊髓炎
医学
光谱紊乱
鉴别诊断
多发性硬化
脱髓鞘病
脱髓鞘病
疾病
广谱
水通道蛋白4
病理
免疫学
精神科
组合化学
化学
作者
Bruna Garbugio Dutra,Antônio José da Rocha,Renato Hoffmann Nunes,Antônio Carlos Martins Maia Júnior
出处
期刊:Radiographics
[Radiological Society of North America]
日期:2018-01-01
卷期号:38 (1): 169-193
被引量:106
标识
DOI:10.1148/rg.2018170141
摘要
Neuromyelitis optica (NMO) is an autoimmune demyelinating disorder for which the aquaporin-4 (AQP4) water channels are the major target antigens. Advances in the understanding of NMO have clarified several points of its pathogenesis, clinical manifestations, and imaging patterns. A major advance was the discovery of the AQP4 antibody, which is highly specific for this disorder. Descriptions of new clinical and radiologic features in seropositive patients have expanded the spectrum of NMO, and the term NMO spectrum disorder (NMOSD) has been adopted. NMOSD is now included in a widening list of differential diagnoses. Acknowledgment of NMOSD imaging patterns and their mimicry of disorders has been crucial in supporting early NMOSD diagnosis, especially for unusual clinical manifestations of this demyelinating disease. This pictorial review summarizes the wide imaging spectrum of NMOSD and its differential diagnosis, as well as its historical evolution, pathophysiology, and clinical manifestations. ©RSNA, 2018 An earlier incorrect version of this article appeared online. This article was corrected on January 15, 2018.
科研通智能强力驱动
Strongly Powered by AbleSci AI