金黄色葡萄球菌
莫匹罗星
杆菌肽
抗菌活性
传统医学
抗生素
化学
微生物学
防腐剂
抗菌剂
耐甲氧西林金黄色葡萄球菌
生物
医学
细菌
遗传学
有机化学
作者
Ruth Bright Chirayath,A. Aparna,R. Jayakumar,Raja Biswas,Lakshmi Sumitra Vijayachandran
标识
DOI:10.1016/j.colsurfb.2019.03.034
摘要
Staphylococcus aureus is a major pathogen causing skin infections and currently treated with topical antibiotic preparations like bacitracin, triple antibiotic ointment (neomycin, polymixin B, and bacitracin), gentamicin or mupirocin. However, their efficacies are restricted when the infections are caused by drug resistant strains. There is an imperative need for new antibacterial compounds for the management of S. aureus topical infections. Maginfera indica (mango) is reported for its antibacterial efficacy in many traditional plant based medicines. In this study we tested the antibacterial efficacy of the methanol extract of mango leaf against SA113 and S. aureus clinical strains. Mango leaf extract (MLE) was found to be an effective anti-staphylococcal agent, non-mutagenic, and contains phytochemicals such as tannins, saponins, flavanoids, phenols, and coumarins. Further, the mango leaf extract (from stock MLE concentration of 130 mg/ml) containing carbopol hydrogel (MLEC) was prepared and characterized further for biocompatibility, rheological and anti-staphylococcal activities. The antibacterial activity of MLEC hydrogel against S. aureus strains was verified using in vitro and ex vivo porcine skin model. Our results demonstrated MLEC hydrogel formulation may act as superior alternative to currently available topical antiseptic/antibiotic formulations for the treatment of drug resistant staphylococcal infections.
科研通智能强力驱动
Strongly Powered by AbleSci AI