胆固醇转移蛋白
医学
内科学
胆固醇
基因型
等位基因
冠状动脉疾病
内分泌学
胃肠病学
心肌梗塞
基因多态性
心脏病学
基因
多态性(计算机科学)
脂蛋白
作者
Güliz Dirimen Arikan,Selim Isbir,Seda Gulec Yilmaz,Turgay Isbir
出处
期刊:in Vivo
[Anticancer Research USA Inc.]
日期:2019-05-01
卷期号:33 (3): 787-792
被引量:3
标识
DOI:10.21873/invivo.11540
摘要
BACKGROUND/AIM Cholesterol ester transfer protein (CETP) is responsible for the transformation of high density lipoprotein (HDL) to low density lipoprotein (LDL) and is a risk factor for atherosclerosis. Our study investigated the association of the rs5883 CETP gene polymorphism with HDL and LDL levels, in 45 coronary artery disease patients and 45 control patients. MATERIALS AND METHODS CETP gene polymorphism was detected using Real Time-Polymerase Chain Reaction (RT-PCR). Lipoprotein levels were measured using Quantimetrix system. RESULTS There were lack of associaition regarding CETP polymorphism in atherosclerosis and HDL and LDL levels (p>0.05) BMI was higher among coronary artery disease patients (CADP) compared to the control group (28.97±6.38, 26.52±4.39 respectively, p<0.03). Frequency of CADP (82.6 %, n=19) who were taking treatment was higher (17.4 %, n=4) (p<0.00). The frequencies of hypertension and type-2 diabetes were higher among CADP (p<0.00). Families of CADP have more CADP (p<0.02). Small HDL particle levels were higher in the control group (p<0.00). CONCLUSION In Turkey, BMI, and frequencies of hypertension and type-2 diabetes were higher among CADP than among healthy controls. Furthermore, the genotypes of the rs5883 CETP gene polymorphism did not differ between CADP and healthy controls.
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