CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol (Adv. Sci. 56/2026)

PFOA/HFPO-TA-Induced Cardiac Senescence Ameliorated by Cycloastragenol Persistent per- and polyfluoroalkyl substances encompassing PFOA and its industrial alternative HFPO-TA pose severe cardiovascular hazards, with HFPO-TA exerting markedly stronger cardiotoxic effects. This cover graphically delineates the overarching mechanistic cascade of pollutant-initiated cardiomyocyte senescence stemming from disrupted mitochondrial homeostasis. Cycloastragenol acts as a natural bioactive protector to mitigate pollutant-elicited cardiac damage. More details can be found in the Research Article by Xin Yao, Jin-Long Li, and co-workers (DOI: 10.1002/advs.77280).