Elaborating Complex Heteroaryl‐Containing Cycles via Enantioselective Palladium‐Catalyzed Cycloadditions

Abstract A general method for asymmetric synthesis of heteroaryl‐containing cycles via palladium‐catalyzed cyclization is reported. Most classes of nitrogen‐containing aromatics, including pyridines, quinolines, pyrimidines, various azoles and the derivatives of nucleobases are compatible substrates, offering various heteroaryl‐substituted cyclopentane, pyrrolidine, furanidine and bicyclo[4.3.1]decadiene derivatives with good to excellent enantioselectivity and diastereoselectivity.