Combination of radical functional group migration (FGM) and hydrogen atom transfer (HAT)

Direct functionalization of C–H bonds is a powerful synthetic tool that unlocks tremendous opportunities for late-stage elaboration of complex molecules. Recent advances of a new strategy, merging radical-mediated functional group migration (FGM) with hydrogen atom transfer (HAT), have shown great potential for site-selective C(sp3)–H bond functionalization. Direct functionalization of C–H bonds is a powerful synthetic tool that unlocks tremendous opportunities for late-stage elaboration of complex molecules. Recent advances of a new strategy, merging radical-mediated functional group migration (FGM) with hydrogen atom transfer (HAT), have shown great potential for site-selective C(sp3)–H bond functionalization.