对映选择合成
对称化
化学
手性(物理)
催化作用
轴手性
有机催化
合成子
卤化
组合化学
有机化学
立体化学
物理
夸克
量子力学
手征对称破缺
Nambu–Jona Lasinio模型
作者
Min Han,Shiqi Zhang,Xin Cui,Qiwei Wang,Guangxun Li,Zhuo Tang
标识
DOI:10.1002/anie.202201418
摘要
Described herein is the enantioselective synthesis of Hantzsch-type 1,4-dihydropyridines (DHPs), which are frequently contained in pharmaceuticals. Readily available symmetrical 1,4-DHPs were used as substrates, and the methyl group at the 2- or 6-position of the 1,4-DHP was selectively monobrominated by desymmetrizing enantioselective bromination. The inert C-H bond was converted into a versatile C-Br bond, which guaranteed the modification of the chiral 1,4-DHP derivatives with high efficiency. Furthermore, axially chiral 4-aryl pyridines were accessible by central-to-axial chirality conversion.
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