喉咙痛
传统医学
药理学
苷元
痰
中医药
医学
生物转化
化学
生物化学
立体化学
糖苷
免疫学
替代医学
病理
酶
作者
Qianqian Li,Tan Yang,Shuang Zhao,Qifeng Zheng,Yaxin Li,Zhiyuan Zhang,Xiuyan Sun,Yan Liu,Yanqing Zhang,Junbo Xie
出处
期刊:Current Drug Metabolism
[Bentham Science]
日期:2022-01-01
卷期号:23 (1): 21-29
被引量:15
标识
DOI:10.2174/1389200223666220202090137
摘要
Platycodonis Radix (Jiegeng), the dried root of Platycodon grandiflorum, is a traditional herb used as both medicine and food. Its clinical application for the treatment of cough, phlegm, sore throat, pulmonary and respiratory diseases has been thousands of years in China. Platycodin D is the main active ingredient in Platycodonis Radix, which belongs to the family of pentacyclic triterpenoid saponins because it contains an oleanolane type aglycone linked with double sugar chains. Modern pharmacology has demonstrated that Platycodin D displays various biological activities, such as analgesics, expectoration and cough suppression, promoting weight loss, anti-tumor and immune regulation, suggesting that Platycodin D has the potential to be a drug candidate and an interesting target as a natural product for clinical research. In this review, the distribution and biotransformation, pharmacological effects, metabolic mechanism and safety evaluation of Platycodin D are summarized to lay the foundation for further studies.
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