间充质干细胞
细胞外基质
自愈水凝胶
再生医学
材料科学
组织工程
再生(生物学)
脚手架
细胞培养
干细胞
三维细胞培养
细胞生物学
纳米技术
生物医学工程
生物
医学
遗传学
高分子化学
作者
Xiaoye Hu,Zengzilu Xia,Kaiyong Cai
摘要
Mesenchymal stem cells (MSCs) have been increasingly recognized as a resource for disease treatment and regenerative medicine. Meanwhile, the unique chemical and physical properties of hydrogels provide innate advantages to achieve high quality MSCs on a large scale. Tremendous kinds of biomaterials have been employed to form hydrogels providing a controllable microenvironment for culturing MSCs. The development of materials science makes it possible to mimic the natural extracellular matrix (ECM), providing an effective means to understand mechanisms such as sensing and remodeling of the different microenvironments by MSCs. The mechanical cues, the formation mechanisms, material types and combination hydrogels are all discussed in this review for three-dimensional (3D) hydrogel culture systems. This article also focuses on the latest development of hydrogel culture systems applied both in vivo and in vitro. Besides the innovation of materials, the culture methods and spatiotemporal cues during the culture stage are other directions of exploration for 3D culture systems. The ultimate goal of hydrogel 3D culture systems is to perfectly mimic the native microenvironment for the study of MSC behavior or the applications of MSC-based therapies.
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