寄主(生物学)
生物
噬菌体
背景(考古学)
航程(航空)
进化生物学
生态学
宿主特异性
基因组
遗传学
基因
古生物学
复合材料
材料科学
大肠杆菌
作者
Patrick A. de Jonge,Franklin L. Nóbrega,Stan J. J. Brouns,Bas E. Dutilh
标识
DOI:10.1016/j.tim.2018.08.006
摘要
The host range of a bacteriophage is the taxonomic diversity of hosts it can successfully infect. Host range, one of the central traits to understand in phages, is determined by a range of molecular interactions between phage and host throughout the infection cycle. While many well studied model phages seem to exhibit a narrow host range, recent ecological and metagenomics studies indicate that phages may have specificities that range from narrow to broad. There is a growing body of studies on the molecular mechanisms that enable phages to infect multiple hosts. These mechanisms, and their evolution, are of considerable importance to understanding phage ecology and the various clinical, industrial, and biotechnological applications of phage. Here we review knowledge of the molecular mechanisms that determine host range, provide a framework defining broad host range in an evolutionary context, and highlight areas for additional research.
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