神经导管
再生(生物学)
周围神经损伤
外围设备
神经生长因子
外周神经系统
神经营养素
电气导管
生物医学工程
周围神经
神经科学
医学
解剖
细胞生物学
中枢神经系统
生物
计算机科学
内科学
电信
受体
作者
Meng Zhang,Heng An,Teng Wan,H. Jiang,Yang Ming,Yongqiang Wen,Peixun Zhang
出处
期刊:International Journal of bioprinting
[Whioce Publishing Pte Ltd.]
日期:2023-06-12
卷期号:9 (5): 770-770
被引量:1
摘要
The micron track conduit (MTC) and nerve factor provide a physical and biological model for simulating peripheral nerve growth and have potential applications for nerve injury. However, it has rarely been reported that they synergize on peripheral nerves. In this study, we used bioderived chitosan as a substrate to design and construct a neural repair conduit with micron track topography using threedimensional (3D) printing topography. We loaded the MTC with neurotrophin-3 (NT-3) to promote the regeneration of sensory and sympathetic neurons in the peripheral nervous system. We found that the MTC@NT3 composite nerve conduit mimicked the microenvironment of peripheral nerves and promoted axonal regeneration while inducing the targeted growth of Schwann cells, which would promote functional recovery in rats with peripheral nerve injury. Artificial nerve implants with functional properties can be developed using the strategy presented in this study.
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