纳米载体
木耳
体内
溶血
抗氧化剂
化学
锌
食品科学
发酵
胃
细胞毒性
生物化学
消化(炼金术)
生物
体外
色谱法
药物输送
生物技术
有机化学
免疫学
作者
Xiaoting Yu,Shanghua Xing,Mingqian Tan
标识
DOI:10.1016/j.foodchem.2024.138386
摘要
Nanoparticles (NPs) possessing nanoscale dimensions and remarkable antioxidant activity were synthesized via a green hydrothermal method utilizing Auricularia auricula fermentation broth, referred to as AFNPs. The functional groups on the surface of the AFNPs significantly contributed to the formation of AFNPs-Zn2+. The AFNPs-Zn2+ appeared a zinc retention rate of 40.80 % after gastrointestinal digestion. When compared to typical zinc supplements, AFNPs-Zn2+ did not exhibit visible cytotoxicity or hemolysis. Furthermore, AFNPs-Zn2+ demonstrated the ability to mitigate cell damage resulting from zinc deficiency. In vivo experiments showed that AFNPs-Zn2+ were mainly observed in the stomach, intestine, kidney, and testis after oral administration. In vivo distribution experiments indicated predominant presence of AFNPs-Zn2+ in the stomach, intestine, kidney, and testis following oral administration. This study highlights the potential for Auricularia auricula NPs to serve as the efficient, stable, and safe nanocarriers for Zn2+.
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