肝细胞癌
医学
肝切除术
内科学
胃肠病学
多元分析
肿瘤科
中性粒细胞与淋巴细胞比率
血小板
癌
淋巴细胞
外科
切除术
作者
Kiyotaka Hosoda,Kentaro Umemura,Akira Shimizu,Koji Koyama,Tsuyoshi Noguchi,Noriyuki Kitagawa,Hiroki Sakai,Hikaru Hayashi,Koya Yasukawa,Yuji Soejima
摘要
The usefulness of inflammation-based prognostic scores for early recurrence (ER) after hepatectomy for hepatocellular carcinoma has rarely been reported. This study aimed to evaluate the potential of inflammation-based prognostic scores as predictors of ER and their relationship with tumor markers.We enrolled 338 patients who underwent hepatectomy for hepatocellular carcinoma between January 2007 and December 2021. Clinicopathological factors were compared between patients who developed ER (ER group) and those who did not develop ER (non-ER group). The association between inflammation-based prognostic scores and ER status was evaluated. These scores were compared with those of well-established tumor markers.The platelet-to-lymphocyte ratio (PLR) correlated with ER of hepatocellular carcinoma, with an area under the curve (AUC) value of 0.70, sensitivity of 68.1%, and specificity of 67.7%. In patients with low tumor marker levels, the PLR showed a strong correlation with ER of hepatocellular carcinoma, with an AUC value of 0.851, sensitivity of 100%, and specificity of 76.2%. Multivariate analysis revealed that the PLR was an independent prognostic factor for ER.The PLR is useful and complementary to tumor markers for predicting ER after hepatectomy for hepatocellular carcinoma.
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