免疫系统
机制(生物学)
生物
免疫原性
分泌物
获得性免疫系统
计算生物学
免疫学
生物化学
哲学
认识论
作者
Liuhong Shen,Haoran Luo,Lei Fan,Xinyu Tian,Alan T. Tang,Xiaofeng Wu,Ke Dong,Zhetong Su
出处
期刊:Molecules
[MDPI AG]
日期:2023-12-23
卷期号:29 (1): 113-113
标识
DOI:10.3390/molecules29010113
摘要
Saponins are extracted from different parts of plants such as seeds, roots, stems, and leaves and have a variety of biological activities including immunomodulatory, anti-inflammatory effects, and hypoglycemic properties. They demonstrate inherent low immunogenicity and possess the capacity to effectively regulate both the innate and adaptive immune responses. Plant saponins can promote the growth and development of the body’s immune organs through a variety of signaling pathways, regulate the activity of a variety of immune cells, and increase the secretion of immune-related cytokines and antigen-specific antibodies, thereby exerting the role of immune activity. However, the chemical structure of plant saponins determines its certain hemolytic and cytotoxicity. With the development of science and technology, these disadvantages can be avoided or reduced by certain technical means. In recent years, there has been a significant surge in interest surrounding the investigation of plant saponins as immunomodulators. Consequently, the objective of this review is to thoroughly examine the immunomodulatory properties of plant saponins and elucidate their potential mechanisms, with the intention of offering a valuable point of reference for subsequent research and advancement within this domain.
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