生物
细胞凋亡
细胞毒性T细胞
癌症
细胞生物学
癌细胞
程序性细胞死亡
癌症研究
疾病
免疫学
体外
病理
遗传学
医学
作者
Shane T. Killarney,Stephen W.G. Tait,Douglas R. Green,Kris C. Wood
标识
DOI:10.1016/j.tcb.2023.07.005
摘要
Abstract
Cytotoxic chemo-, radio-, and targeted therapies frequently elicit apoptotic cancer cell death. Mitochondrial outer membrane permeabilization (MOMP) is a critical, regulated step in this apoptotic pathway. The residual cancer cells that survive treatment serve as the seeds of eventual relapse and are often functionally characterized by their transient tolerance of multiple therapeutic treatments. New studies suggest that, in these cells, a sublethal degree of MOMP, reflective of incomplete apoptotic commitment, is widely observed. Here, we review recent evidence that this sublethal MOMP drives the aggressive features of residual cancer cells while templating a host of unique vulnerabilities, highlighting how failed apoptosis may counterintuitively enable new therapeutic strategies to target residual disease (RD).
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