SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL TEST AND MOLECULAR DOCKING OF SOME AMIDE DERIVATIVES

The amide group is an organic group synthesized by reaction between an amine and carboxylic acid and is known to have many biological activities like antibacterial, antifungal, anti-inflammatory, antitumor and many other activities.the traditional and easy method to synthesize amides by first convert carboxylic acid to acyl chloride and then the acyl chloride react with amine to give the amide .the goal is to synthesize new amide derivatives by one pot reaction between two drugs one is amine ( bromohexine which act as mucolytic) And the other drug is carboxylic acid like NSAIDs ( diclofenac, naproxen, indomethacin and mefenamic acid) using thionyl chloride and triethylamine as catalytic agents and stirring for 1 hr. The result products will be characterized by physical examination, melting point and IR spectroscopy. As mentioned the amide derivatives have many biological activities so the antibacterial activity will be tested on some bacterial species 2 g+ve( staph.aureus and streptococcus) and 2 g-ve ( E.coli and Klebsiella). Finally the docking study will be done on the synthesized derivatives on the proposed targets to see the inhibition score for each derivatives and compare it with the reference inhibitor and with antibacterial test.