CD4 + Effector Memory T Cells Related Marker Gene Signatures in Osteoporosis and Aging: Insight From Single-Cell Analysis and Mendelian Randomization

This study conducted a comprehensive analysis of the potential link between OP and aging, identifying CD4⁺ T_EM cells as the core cell subgroup in OP and aging samples. It further revealed the causal relationship between KLRB1, NR4A2, and S100A4 and the occurrence of OP. The upregulation of KLRB1 and S100A4 may contribute to OP pathogenesis by promoting interactions between CD4⁺ TEM cells and other cell subgroups, providing new insights for molecular targeting and immunotherapy of OP.