Fabrication of High-aspect Ratio Biopolymeric Microneedles for Biomedical Applications

We report maskless fabrication of high-aspect ratio microneedles (MNs) in biopolymer-chitosan via femtosecond laser-assisted two-photon lithography and molding, enabling the fabrication of MNs up to 500 µm height while preserving its inherent chemical functionalities post-fabrication.