Coexistence of APC and KRAS Mutations in Familial Adenomatous Polyposis and Endometrial Cancer: A Mini‐Review With Case‐Based Perspective

ABSTRACT Familial adenomatous polyposis (FAP) is a well‐characterized hereditary colorectal cancer syndrome driven by germline mutations in the APC gene. KRAS mutations, although more common in sporadic colorectal and endometrial cancers, are rarely seen concurrently in patients with FAP. This mini‐review summarizes the current understanding of the molecular mechanisms of APC and KRAS mutations in FAP and their rare coexistence in extracolonic malignancies, particularly endometrial cancer. A rare case of a 48‐year‐old female with both FAP and endometrial cancer harboring APC p.G1357Efs*58 and KRAS p.G12V mutations is included to contextualize the clinical relevance.