聚酯纤维
聚合
微球
组分(热力学)
分散聚合
高分子化学
色散(光学)
高分子科学
化学工程
共聚物
材料科学
化学
有机化学
聚合物
热力学
物理
光学
工程类
作者
Xiaolei Zhang,Xiaofei Sun,Le Zhou,Le Chang,Yan Zhang,Yingxia Zong,Jingjiang Sun,Qingfu Wang
出处
期刊:Macromolecules
[American Chemical Society]
日期:2025-04-22
卷期号:58 (10): 5037-5048
标识
DOI:10.1021/acs.macromol.5c00071
摘要
Aqueous dispersion polymerization, predominantly based on the mechanism of radical polymerization, presents inherent limitations for polyester preparation through polycondensation or ring-opening polymerization approaches due to the substantial presence of water molecules. Herein, we report a facile and versatile strategy for the preparation of polyester microspheres (PEMs) via Passerini three-component dispersion polymerization (P-3CDP) under ambient aqueous conditions. By optimizing the polymerization parameters, we successfully synthesized a library of PEMs featuring diverse main-chain structures, including aliphatic carbon chains and functional backbones incorporating phenyl, alkenyl, biobased isosorbide, and furfuryl moieties, as well as reduction-responsive disulfide and pH-responsive Boc-protected l-glutamic acid groups. Comprehensive characterization of the resulting PEMs, including their chemical structures, microsphere morphologies, molar masses, and thermal properties, was performed using 1H NMR, SEM, DLS, SEC, and DSC measurements. CCK-8 assays with mBMSC cells were conducted to assess the cytotoxicity and verify biological safety. Taking the PEM containing a Boc-protected l-glutamic acid backbone as an example, its pH-responsive self-immolative property was verified, suggesting the feasibility of straightforward preparation of stimuli-responsive PEMs through the aqueous P-3CDP method.
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