纳米医学
阿霉素
体内
药代动力学
癌症研究
毒品携带者
正电子发射断层摄影术
分布(数学)
癌症
药理学
材料科学
药品
生物医学工程
化学
医学
化疗
纳米技术
核医学
内科学
生物
纳米颗粒
生物技术
数学
数学分析
作者
Libor Kostka,Lenka Kotrchová,Eva Randárová,Carolina A. Ferreira,Iva Malátová,Hye Jin Lee,Aeli P. Olson,Jonathan W. Engle,Marek Kovar,Weibo Cai,Milada Šírová,Tomáš Etrych
标识
DOI:10.1016/j.jconrel.2022.11.060
摘要
Nanomedicines are considered next generation therapeutics with advanced therapeutic properties and reduced side effects. Herein, we introduce tailored linear and star-like water-soluble nanosystems as stimuli-sensitive nanomedicines for the treatment of solid tumors or hematological malignancies. The polymer carrier and drug pharmacokinetics were independently evaluated to elucidate the relationship between the nanosystem structure and its distribution in the body. Positron emission tomography and optical imaging demonstrated enhanced tumor accumulation of the polymer carriers in 4T1-bearing mice with increased tumor-to-blood and tumor-to-muscle ratios. Additionally, there was a significant accumulation of doxorubicin bound to various polymer carriers in EL4 tumors, as well as excellent in vivo therapeutic activity in EL4 lymphoma and moderate efficacy in 4T1 breast carcinoma. The linear nanomedicine showed at least comparable pharmacologic properties to the star-like nanomedicines regarding doxorubicin transport. Therefore, if multiple parameters are considered such as its optimized structure and simple and reproducible synthesis, this polymer carrier system is the most promising for further preclinical and clinical investigations.
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