47. The Structural Connectome Shapes Grey Matter Changes Across the Psychosis Continuum

Different regions of the brain’s grey matter are connected by a complex network of white-matter fibres, which are responsible for the propagation of action potentials and the transport of trophic and other molecules. In neurodegenerative disease, these connections constrain the way in which grey-matter volume (GMV) abnormalities progress. Here we investigated whether connectome architecture also shapes the spatial pattern of GMV abnormalities across multiple stages of psychotic illness.