Skin autofluorescence measurement in diabetological and nephrological clinical practice

Formation of advanced glycation end-products plays role in the pathogenesis of diabetic complications and related ongoing connective tissue degeneration as part of atherosclerosis and chronic kidney disease. The cumulative metabolic burden of patients can be measured in few minutes using a recently developed non-invasive mobile device, which has been developed for the evaluation of fluorescent advanced glycation end-product molecules in skin. The variation of skin autofluorescence measurement is about 10%, and its predictive value in cardiovascular events overcomes conventional glycemic markers even in chronic kidney disease population. In the early stages of diabetes it seems to be an effective screening tool, and in overt diabetes signifies micro- and macrovascular complications. This method is unadaptable in systemic autoimmune diseases, generalised dermatological illnesses and hepatobiliary pathological conditions leading to icterus. Significant correlation has been found between skin autofluorescence and pulse wave velocity due to glycation of vascular wall structure proteins and consequent arterial matrix rigidity. Orv. Hetil., 2012, 153, 1651–1657.