医学
骨髓
淋巴细胞白血病
肿瘤科
内科学
髓腔
疾病
细胞遗传学
急性淋巴细胞白血病
白血病
骨髓移植
免疫学
骨髓移植
基因
生物
生物化学
染色体
作者
Santiago Riviello-Goya,Aldo A. Acosta‐Medina,Sergio I Inclán-Alarcón,Sofia Garcia-Miranda,Christianne Bourlon
出处
期刊:Oncology
[MJH Life Sciences]
日期:2020-02-13
卷期号:34 (2): 39-43
被引量:2
摘要
• Isolated EMR is defined as the presence of clonal blasts in any tissue other than the medullary compartment with a bone marrow evaluation with less than 5% clonal blasts and a full donor chimerism. • Patients with iEMR have shown better survival outcomes when compared to BMR and EMR and in most cases it heralds a systemic relapse. • Risk factors for iEMR include: younger age, history of EMD, poor risk cytogenetics, advanced disease at HSCT, development of GVHD, and non-TBI based conditioning regimens. • Combination therapy, local and systemic, can achieve better remission rates in this subgroup of patients.
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