生物
顺铂
癌症研究
DNA修复
同源重组
胰腺癌
雷达51
医学
同源染色体
后天抵抗
转录组
基因
癌症
抗药性
化疗
重组
突变
DNA转座因子
肿瘤科
免疫学
生物信息学
作者
Muhammad Umair Latif,Xuean Liu,A Bockelmann,L Huhnold,G. Schmídt,Lukas Klein,Xueyuan Zhao,LC Conradi,Karly Conrads,Audrey Weber,Sercan Mercan,K Reutlinger,Atmika Paul,Zeynab Najafova,Steven A. Johnsen,Zuriñe Bonilla del Rio,Frederike Penz,Jovan Todorović,Holger Bastians,Tim Beissbarth
出处
期刊：Gut
[BMJ]
日期：2025-12-31
卷期号：: gutjnl-2025
标识
DOI：10.1136/gutjnl-2025-336227
摘要
We have identified a highly aggressive GSK3βhigh/NFATc1high subtype that predicts early recurrence, poor survival and cisplatin resistance in PDAC. This subtype reveals new treatment vulnerabilities suggesting that patients with PDAC may benefit from stratification-based tailored treatment strategies.
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(2025-6-4)
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