A General Iron-Photocatalyzed Decarboxylative Arylalkylation of Carboxylic Acids with Activated Alkenes

We present a ligand-to-metal charge transfer (LMCT)-enabled, iron-photocatalyzed decarboxylative arylalkylation protocol for coupling readily accessible N-arylacrylamides with commercially available, structurally diverse carboxylic acids, furnishing various alkylated amides bearing acyclic quaternary stereocenters or cyclic alkylated oxindoles with high chemoselectivity. The protocol is applicable to a wide range of carboxylic acid substrates, encompassing primary, secondary, and tertiary alkyl carboxylic acids, along with structurally complex bioactive carboxylic acids.