渗透
人体皮肤
分配系数
色谱法
化学
膜
体外
背
磁导率
表皮(动物学)
水溶液
生物化学
生物
解剖
有机化学
遗传学
作者
Aroonsri Priprem,Chidchanok Khamlert,Thaned Pongjanyakul,S. Radapong,Theera Rittirod,Padungkwan Chitropas
出处
期刊:American Journal of Agricultural and Biological Sciences
[Science Publications]
日期:2008-03-31
被引量:5
标识
DOI:10.3844/ajabssp.2008.444.450
摘要
Scales of shed king cobra (Ophiophagus hannah) skin from the dorsal portions, (SSS) and human breast epidermis (HE) were used as barrier membranes for comparison in an in vitro drug permeation study of nine active compounds (MW range 150-300 g mol-1, pKa 3-10). Each compound, saturated in a donor solution at pH 4.0 or 5.6, permeated through the barrier membrane, fully hydrated. A receptor solution at pH 7.4 was sampled for quantification at its λmax by UV-Visible spectrophotometry and/or HPLC. The permeability coefficients of nine compounds were correlated to the n-octanol/water partition coefficients of these compounds. The permeability coefficient of these compounds using HE and SSS was correlated. Scales of shed skin from the dorsal portions of king cobras were shown to be well correlated to the human breast epidermis in this in vitro aqueous permeation study of these compounds.
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